Elucidating Regulatory Mechanisms Downstream of a Signaling Pathway Using Informative Experiments Supplementary Information
نویسندگان
چکیده
1 Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany, 2 International Max Planck Research School for Computational Biology and Scientific Computing, Berlin, Germany, and 3 Institute of Informatics, Warsaw University, Banacha 2, 02-097, Warsaw, Poland 4 Present address: Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA * Corresponding author. E-mail: [email protected]
منابع مشابه
Elucidating regulatory mechanisms downstream of a signaling pathway using informative experiments
Signaling cascades are triggered by environmental stimulation and propagate the signal to regulate transcription. Systematic reconstruction of the underlying regulatory mechanisms requires pathway-targeted, informative experimental data. However, practical experimental design approaches are still in their infancy. Here, we propose a framework that iterates design of experiments and identificati...
متن کاملStudy of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks
Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...
متن کاملInteraction of viral oncogenic proteins with the Wnt signaling pathway
It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...
متن کامل15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner
Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...
متن کاملPrediction of MicroRNAs bind to Toll-like Receptors Pathway in Chicken based on Bioinformatics Method
Background: Toll-like receptors (TLRs) detect diverse pathogen-associated molecular patterns and play a critical role in the innate immune response. Hosts should activate TLR-signaling pathways to eliminate invading pathogens. However, excessive activation of these pathways may interrupt immune homeostasis, leading to several diseases. Therefore precise regulation of TLR-signaling pathways is e...
متن کامل